The Buffalo Bills and Tennessee Titans will play at Tottenham Hotspur Stadium next season.
The Jacksonville Jaguars will also return to the UK for the 10th time since their first game in 2013 for a game at Wembley Stadium.
The Kansas City Chiefs and New England Patriots will have games in Germany during the 2023 season.
Although the five “home” teams have been named, match dates and opponents for each team have yet to be announced.
The NFL hosted their first regular season game in Germany earlier this season, on a four-year deal announced in February 2022, with Munich and Frankfurt as host cities.
Five international matches were played last season, including one in Mexico, but an additional game will be played in Germany next season as renovations are underway at the Azteca stadium in Mexico City.
“We know how important live regular season games are to our global fans,” said NFL Executive Vice President Peter O’Reilly.
“Growing the league and our sport internationally is a top strategic priority for the NFL, and we’re excited to play five games outside of the United States again in 2023.”
The Jaguars had already made a multi-year commitment to play one game per season in London, which is currently taking place until the 2024 season included.