Fast bowler Jofra Archer was ruled out for the summer but Jonny Bairstow returned to the England Test squad as wicketkeeper in place of Ben Foakes.
Bairstow, who has not played for England since breaking his leg in August, will take up the gloves against Ireland on June 1.
Fast bowler Archer has a recurrence of the stress fracture in his right elbow.
James Anderson is named to the 15-man squad despite suffering a groin injury while playing for Lancashire.
The four-day test against the Irish at Lord’s is England’s latest preparation for the Ashes series against Australia, which kicks off on June 16.
England team: Ben Stokes (Captain Durham), James Anderson (Lancashire), Jonny Bairstow (Yorkshire), Stuart Broad (Nottinghamshire), Harry Brook (Yorkshire), Zak Crawley (Kent), Ben Duckett (Nottinghamshire), Dan Lawrence (Essex), Jack Leach (Somerset), Ollie Pope (Surrey), Matthew Potts (Durham), Ollie Robinson (Sussex), Joe Root (Yorkshire), Chris Woakes (Warwickshire), Mark Wood (Durham).
Anderson is joined by Stuart Broad, Ollie Robinson and Matthew Potts in the fast bowling department, while Mark Wood provides a fast option after missing the 1-1 draw in New Zealand.
There is also a recall for Chris Woakes, who last played a Test in March last year and has yet to feature since captain Ben Stokes and coach Brendon McCullum took charge. .
Drummer Ollie Pope has been officially confirmed as Stokes vice-captain after leading England in warm-up games this winter. His elevation is significant, given Stokes’ recent issues with a longstanding knee complaint.
Foakes of Surrey, 30, can consider himself unhappy. Regularly labeled by Stokes as “the best wicketkeeper in the world”, he has been a regular for England in their run of 10 wins in their last 12 matches.
However, after Bairstow suffered his freak injury while slipping on a golf course, his replacement Harry Brook had a stellar start to his Test career, scoring four hundred in six matches.
That left England with a dilemma of how to welcome the return of Bairstow, who himself shattered six centuries in 2022 before sustaining the injury.
Any suggestion of rearranging the batting order was still unlikely – some even advocated Stokes as the opener – leaving a straight choice between Bairstow and Foakes.
Bairstow, 33, saved 49 of his 89 tests and will take his place behind the stumps for the first time since September 2021.
“It was a very difficult decision to leave Ben Foakes out of the squad. He was great for England last year but Jonny Bairstow is one of the best players in the world whose performances last summer embodied who we are,” said England cricket manager Rob Key.
The new elbow injury is the latest setback for Archer, 28, who hasn’t played a Test since February 2021.
After a series of back and elbow problems, Archer returned to play white-ball cricket for England earlier this year.
However, he returned early from his stint with Indian Premier League side Mumbai after suffering further discomfort in his elbow and a scan revealed the stress fracture.
He will spend time recovering with medical teams in England and his county of Sussex, but there must now be huge doubts over whether Archer will ever add to his 13 Test caps.
“It’s been a frustrating and upsetting time for Jofra Archer,” Key said.
“He was making good progress until a recurrence of the elbow injury, which had kept him out for a long time before.
“We wish him the best of luck with his recovery. I’m sure we’ll see Jofra in his best games and win for England, whatever the format. Hopefully sooner rather than later.”
“England chooses the firelighter over the fireman”
Analysis by BBC cricket editor Stephan Shemilt
Despite all the talk about changing the batting order to accommodate the return of Jonny Bairstow, it was still likely that Ben Foakes was the most vulnerable.
Realistically, Foakes lost his place to Harry Brook, whose four centuries in six tests demanded inclusion.
There will be concern that England opted for Bairstow runs over Foakes’ top glove – Cricviz ranks Foakes as the best keeper to play 10 or more Tests since 2016 and his impact with the gloves gives him a 10 point advantage over Bairstow on the course of a test.
But Bairstow is no novice behind the stumps. An 88% catch completion rate in the 49 tests he took with the gloves is even better than Foakes’ 81%.
Foakes has been a reliable presence in England’s middle order – a firefighter who can navigate from danger when the flash players in front of him have burned their fingers.
He played important innings in defeats to New Zealand at Lord’s, South Africa at Old Trafford and Pakistan at Karachi.
Bairstow, however, can bring pyrotechnics and is more likely to win a test from number seven.
Realistically, he will scare Aussies more and a line-up of Joe Root, Brook, Ben Stokes and Bairstow looks exciting.
Foakes may be the fireman, but to get Ashes you need fire and England went for the firestarter.
